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PT-141 was engineered for improved selectivity toward MC4R with reduced MC1R activity, eliminating the tanning effect while retaining central arousal pathway activity
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Thus, GIP is a likely candidate for mediating some of the therapeutic actions of DPP-4 inhibition, and the recent development of a GIP receptor antagonist suitable for use in clinical studies (50) should allow this hypothesis to be tested
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A smaller measured volume does not automatically mean a safer dose
