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Each GLP-1 medication has its own dosing schedule
If the half-life is 7 days, why does it take 4-5 weeks to reach a steady state
This occurs due to irritation of the urinary tract lining as the stone passes
Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers
LY3437943 (Retatrutide): discovery to clinical proof of concept (triple GLP-1/GIP/glucagon agonist, preclinical mechanism) Nature Reviews Endocrinology (2024) Multi-receptor agonists for metabolic disease (mechanism of GLP-1/GIP/glucagon co-activation) Diabetes Care (2024) Incretin-based therapies: GLP-1, GIP, and glucagon receptor pharmacology (metabolic pathways, energy expenditure) NEJM (2023) Supplementary Material Jastreboff et al
This is not unusual and reflects the complex interplay of slowed gastric emptying (which promotes constipation) and altered intestinal motility (which can trigger diarrhea)
