Result: GLP-1s lowered osteoporosis risk (31% reduction)
S16, S17)
To further evaluate the effects of GLP-1 analogs on muscle mass, four types of skeletal muscles (soleus, gastrocnemius, tibialis anterior, and extensor digitorum longus) were independently measured after 3 weeks of treatment
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231 Mechanistically, ketones produced by liver metabolism act as both energy supply molecules and signal molecules involved in binding G protein-coupled receptors, inhibiting HDACs, regulating the abundance of intestinal microbiota, improving intestinal barrier function, and reducing the production of ROS and free radicals