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The medication works by mimicking two naturally occurring hormones in the body that regulate appetite and blood sugar levels

American Journal of Medicine, 138(2), 210222

Specifically, it is obvious that the newly formed Arg123-Glu40 salt bridge is due to the missense mutation L23B R (Figure 2), i.e., the substitutin of the leucine with a positively charged arginine at position 23 of semaglutides backbone (Figure 2)