Patients should: Follow the dose escalation schedule to minimise side effects Attend regular follow-up appointments to monitor progress and safety Engage with dietetic support to ensure adequate nutrition whilst reducing calorie intake Combine medication with increased physical activity (aim for 150 minutes moderate-intensity exercise weekly, plus muscle-strengthening activities on at least 2 days per week, as per UK Chief Medical Officers' guidelines) Structured lifestyle programmes : NICE recommends multicomponent interventions including dietary modification, physical activity, and behavioural strategies
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Difficulty with Memory or Concentration Vitamin B12 deficiency may affect brain function and contribute to difficulty with memory, focus, or concentration
It often requires follow-up visits, progress evaluations, treatment adjustments, and continued support
The dose escalation in days 16-30 is designed to reinforce the signaling pathways activated in Phase 1