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Significantly, a compound denoted as melatonin-trientine, covalently synthesized with melatonin and the metal ion chelator trientine, demonstrated the capacity to elevate the expression of IDE in a murine AD model, and decreased A deposition and neuronal degeneration in the brains of the APP/Presenilin 1 mice [65]

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MT-II is a shorter cyclic heptapeptide with a lactam bridge

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PICRUSt2 analysis demonstrated enhanced microbial pyruvate and butanoate metabolism pathways, and correlation analyses revealed close relationships among microbiota, SCFAs, and muscle parameters