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Several studies show that metformin can increase plasma active GLP-1 level through enhancing GLP-1 secretion from intestinal L cells 21 or inhibiting dipeptidyl peptidase 4-mediated GLP-1 degradation 22,23

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Obesity induces ovarian inflammation and reduces oocyte quality

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These findings support continued development of #nimacimab as a novel, non-GLP-1 therapeutic targeting #CB1 inhibition for #obesity

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