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Conclusion Clinical trial data from large, controlled studies demonstrate the efficacy and safety of GLP-1 agonists in terms of A1C reduction, beneficial effects on body weight, and a low risk for hypoglycemic events when used as monotherapy
The ensuing negative feedback loop may involve not only EECs but also Paneth cells and intestinal intraepithelial lymphocytes, as these cells have been reported to express the receptor for GLP-1 (namely GLP-1R), and loss of GLP-1R increases the severity of DSS-induced intestinal injury8, 9
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May be kept at temperatures up to 30C for up to 14 days before use
The Endocrine Society's 2018 guidelines on testosterone therapy specify that men on TRT should have hematocrit checked at 3 to 6 months after initiation and annually thereafter, because testosterone can increase red blood cell production to dangerous levels (polycythemia) [16]
