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The results show a clear dose-response relationship: At 4mg weekly, participants in the Phase 2 trial achieved approximately 17.5% mean body weight reduction over 48 weeks
Unlike GLP-1 agonists, the changes are compositional rather than scale-weight driven: patients may not lose significant total body weight but will show meaningful reduction in waist circumference and visceral fat volume
The facial fat pads shrink along with weight elsewhere
Diabetes Obes Metab (2020) 22(12):248792
It is envisioned that a specific AIE probe can be designed by decorating the TPE core with a particular functional group 26,57
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