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Categories Food Product Development Obesity and Weight Management Diet and Health R and D Food Technology Magazine Innovation
Extra weight and insulin resistance reduce GLP-1 secretion as well as beta cell (insulin-secreting cells in the pancreas) responsiveness
They may increase vulnerability in sensitive individuals, so closer monitoring is recommended
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D.et al (1999)
In atherosclerotic disease, GLP-1RAs have been shown to attenuate and stabilize development of atherosclerotic plaques through anti-inflammatory mechanisms (inhibition of IL-6 and TNF-, and NF-B), inhibit activation and recruitment of macrophages and prevent vascular remodeling
