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Vitamin B12 is not known to interact with any medications taken specifically for RA

Our analysis of kidney stone as a negative control outcome showed a null association, reassuring that the results are robust to unmeasured/residual confounding

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Run order of samples was randomized and in lieu of internal standards, technical replicates were injected every 8 samples to assess quality control and instrument performance

Cell multiplication While B12 is cofactor, methylfolate is the methyldonor in the above process

However, some individuals may prefer evening administration, particularly if they experience any mild detoxification effects that might be better tolerated during sleep