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Animal models of myocardial infarction show that TB-500 administration improves left ventricular function, reduces infarct size and cardiomyocyte death during ischemic events, and enhances cardiac microvascular density to improve tissue perfusion

Many clinical observations suggest use 2-3 times per week rather than daily, with cycling periods to help maintain response over time

Neurologic manifestations will not be prevented with folic acid, and if not treated with vitamin B 12, irreversible damage will result

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