It also has a tyrosine residue to replace the first amino acid at the N-terminus, which researchers consider to help increase the stability of the peptide
(2013) Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans J Endocrinol Metab 3(12):715 AOD9604 vs Related GH-Axis Research Tools AOD9604s unique combination of GH receptor independence, direct lipolytic activity, absence of IGF-1 stimulation, and confirmed oral bioavailability makes it an irreplaceable research tool for studying adipose tissue metabolism and lipolysis without the systemic endocrine confounds associated with intact hGH or indirect GH secretagogues
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Gallbladder events : As with other incretin-based therapies, there is a potential risk of gallbladder disease, including cholelithiasis (gallstones)
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Active cardiovascular event: TB-500 does have a studied cardiac application in stable post-heart attack patients (Zhu et al., 2016), but using it during an active cardiac event without a physician's supervision falls outside any validated protocol