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[2] Research indicates that ALA may improve symptoms of diabetic neuropathy: for example, clinical trials and meta-analyses have shown that intravenous ALA (typically 600 mg per day for 3 weeks) may significantly reduce neuropathic pain, paresthesia, and numbness in diabetic patients

However, the therapy at this dosage also led to a high incidence of side effects such as joint pain (50% of patients) and swelling in the limbs (37% of patients) [13]

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