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Konig SA, Siemes H, Blaker F, Boenigk E, Gross-Selbeck G, Hanefeld F, Haas N, Kohler B, Koelfen W, Korinthenberg R: Severe hepatotoxicity during valproate therapy: an update and report of eight new fatalities

The most commonly applied BPC-157 protocol for acute injury repair runs four to six weeks of daily administration, followed by a rest period of equal duration before reassessment

doi: 10.1016/j.sjpain.2016.07.004

This is more likely to occur in people with underlying heart conditions

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While these findings have not been linked to serious adverse outcomes so far, they highlight the need for long-term safety studies, which are currently underway in Phase 3 trials