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[34] The heterogeneous clinical phenotypes of the metabolic disease combined malonic and methylmalonic aciduria (CMAMMA) due to ACSF3 deficiency are thought to result from partial compensation of a mitochondrial isoform of ACC1 (mtACC1) for deficient ACSF3 in mitochondrial fatty acid synthesis (mtFAS)

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The 28.7% weight loss and 82% liver fat reduction could justify this designation, particularly for MASLD, which currently has limited treatment options

Short-course studies report no overt toxicity at commonly used doses, but programs should include organ-system panels, cardiovascular telemetry where relevant, and pathology review for chronic exposures

doi: 10.3389/fendo.2019.00155 129 DuarteAICandeiasECorreiaSCSantosRXCarvalhoCCardosoSet al

Key benefits of Selank/Semax Nasal Spray : Anxiety reduction without sedation