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While weight loss undoubtedly plays a major role, the magnitude and speed of hormonal recovery along with increases in gonadotropins (LH, FSH) and SHBG [sex hormone-binding globulin] suggest that tirzepatide may exert additional regulatory effects on the hypothalamic-pituitary-gonadal axis. Klindukhova commented, from an endocrinologist standpoint, if theres a patient who is open to it, I would personally go for GLP-1 over testosterone. Cannarella, Klindukhova, and Stefanovic-Racic had no disclosures
Most can stop taking it once they reach a healthy BMI which is between 18.5 - 24.9
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Sub-99% purity introduces synthesis impurities that can bind off-target, alter pharmacokinetics, or produce confounding biological effects
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