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These mutations alter the activity of the encoded enzymes such that instead of converting isocitrate to 2-oxoglutarate (-ketoglutarate), while also generating NADPH, the mutant IDH enzymes reduce 2-oxoglutarate (-ketoglutarate) to 2-hydroxyglutarate (2-HG) while simultaneously oxidizing NADPH to NAPD +
DOI: 10.1038/nrn1583 Schwartz M et al (1990): Oral nifedipine in the treatment of hypertensive urgency: cerebrovascular accident following a single dose
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