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J Biol Chem (2004) 279(22):2315865.10.1074/jbc.M314322200 202 SayinSIWahlstrmAFelinJJnttiSMarschallHUBambergKet alGut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist
While oral GLP-1 pills promote significant weight loss (typically 10%13% of body weight), weekly subcutaneous injections like semaglutide and tirzepatide remain superior, yielding average weight losses of 15% to 22.5% in clinical trials
In rare cases, other serious side effects can occur, including anaphylaxis
doi: 10.1016/j.clnesp.2020.03.008
Studies testing vaccines based on virus-like particles are just beginning to emerge
The alterations in the microbial makeup of the small bowel align with fluctuations in the activity of genes associated with absorbing glucose and fatty acids in the intestines, amplifying the positive metabolic impacts of metformin (Bauer et al., 2018
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