does glp 1 cause you to lose muscle Comment “Curious” for the deep dive 👇 A new 2026 study suggests we might have been totally wrong about GLP-1s and mass loss. These data suggest GLP-1 receptor agonists may not Muscle matters when you're taking

When semaglutide is inadvertently injected into muscle tissue rather than subcutaneous fat, the effects are not well-documented as this route was not studied in clinical trials

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In hepatocytes, hexokinase activity is dependent on the insulin/glucagon ratio for the removal of excess glucose from the blood and its targeting to the glycolytic or glycogenesis pathway, through stimulation of glucose-induced glycogen synthesis 20,21

doi: 10.1007/s00467-009-1435-z

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Patients interested in emerging options can review comparisons like Ozempic versus retatrutide to understand how next-generation compounds might eventually expand the available choices