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It is also known that carnitine supplementation in dairy cows produces variable results depending on dose and delivery route ( Lacount et al., 1995
Thus, folate builds up in the form of 5mTHF (the "methyl trap") and there is less folate in the forms CH 2 -THF and 10f-THF that are the substrates for thymidylate and purine synthesis, respectively
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There is a theoretical concern that very high doses may interfere with certain chemotherapy drugs that rely on oxidative mechanisms, so individuals undergoing cancer care should consult their oncologist before supplementing
Peichoto et al
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