tirzepatide surmount-1 weight loss percent nejm 2022 π Semaglutide 2.4mg: β13.7% (SURMOUNT-5 head-to-head), π 15mg: β20.2% weight loss (same trial, 2025), π Retatrutide 12mg: β28.7% weight loss (TRIUMPH-4, Phase 3, Dec Tirzepatide as Compared with Semaglutide
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