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Like most medications, Semaglutide may have side effects, although they tend to be mild and temporary
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A recent meta-analysis employing a random-effects model revealed a prevalence of 14,6% in patients with obesity [73]
Worth a read for anyone following obesity care and real-world evidence: To view or add a comment, sign in A diagnostic paradox buried in the Lancet obesity framework: Patient A: HbA1c 6.1% + dyslipidemia meets definition of "clinical obesity" Patient B: HbA1c 6.8% (diagnosed T2DM) + normal lipids may not qualify as "clinical obesity" T2DM was excluded from the organ-dysfunction criteria despite: ~90% of T2DM patients being overweight or obese Strong mechanistic links to visceral & ectopic fat ~50% diabetes remission rate with intensive weight loss at 1 year This inconsistency may create real coverage and access problems
However, it is encouraging that preclinical and early human studies suggest that GLP-1 agonism appears broadly protective: indeed clinical trials of these agents are being initiated in cardiovascular disease (SELECT and SOUL trials, see below), NASH, and neurodegeneration (Alzheimers and Parkinsons)
A total of 28 types of collagen have been identified till date, but the most important ones for skin, bones, and connective tissues are Types I, II, III, IV, and V
