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Others have mild to moderate symptoms such as: Fatigue Weakness Pale skin Dizziness Feeling cold Due to decreased oxygen supply to cells in the body, thalassemia can also cause signs and symptoms such as: Growth delays Osteoporosis (weak bones) Enlarged spleen People with severe thalassemia can have the above symptoms as well as: Decreased appetite

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BDNF is also involved in regulation of migration of neuronal progenitors along the rostral migratory stream and neuronal settlement in the olfactory bulb (Snapyan et al

Hereditary cancer syndromes like BRCA1/2 mutations, Lynch syndrome, and Li-Fraumeni syndrome create elevated lifetime cancer risk that persists regardless of current cancer status