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Amino acid sequence determination of human S100A12 (P6, calgranulin c, CGRP, CAAF1) by tandem mass spectrometry

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During the early stages of inflammation, melatonin functions transiently as a proinflammatory agent for 23 hours, which is necessary for adaptation to acute stress.35 However, in later stages, it suppresses inflammation by inhibiting the binding of NF-B to DNA and downregulating Cyclooxygenase-2 (COX-2) expression.36 Similarly, intracellular GSH levels typically decrease during early inflammation, which can trigger NF-B activation and promote the production of essential proinflammatory cytokines

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