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Mechanistically, melatonin acted independently of canonical melatonin receptors and instead reprogrammed ILC2 metabolism toward pentose phosphate pathway activity, enhancing NADPH generation and NRF2-dependent glutathione accumulation

Sun H, Zhao A, Gao N, Li K, Ren J, Qu X

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The problem is that production drops dramatically with age

Glutathione, a first line of defense against cadmium toxicity

We report that small intestinal epithelial cells (IECs) in Crohns disease (CD) exhibit impaired GPX4 activity and signs of LPO