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(C) OGTT with 2 g/kg glucose gavage in mGlp-1r , hGLP-1R, and Glp-1r / mice after an overnight fast

To ensure accurate outcome assessment, we excluded patients who experienced any of the prespecified outcomes before their index date

Low levels of exogenous CCK-8 administration (4 ng/kg/min IV) have also been shown to decrease food intake in both lean and obese humans 175 , and intraperitoneal injection of CCK-8 decreases food intake in rats in a dose-dependent manner 176

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[5] [6] If more than five days have passed, the missed dose should be skipped