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2017a, b, c)In addition, an aberrant gene expression profile is linked to the mitochondrial phenotype observed in DS, characterized by reduced respiratory efficiency, changes in mitochondrial morphology, altered oxidative metabolism, and impaired mitochondrial biogenesis (Izzo et al
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L.et al (2020)
Understanding the potential indirect mechanismsincluding rapid weight loss, electrolyte disturbances, and dehydrationcan help patients and clinicians manage these symptoms effectively
Both build upon the established foundation of GLP-1 receptor activation but expand the mechanism in distinct ways
These gene signatures are then mapped to the list of curated biological pathways, revealing key dysregulated processes
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