The dosage and administration of Cyanocobalamin are determined by a healthcare provider based on the patients age, medical condition, and the severity of the B12 deficiency
D is the 3.2 mg KLOW dose, M is the vials total 80 mg, and V_draw is the selected draw volume in mL: V water = V draw M D Worked example: 3.2 mg total KLOW in a 0.2 mL, or 20-unit, draw
In the mucosal cells of the distal ileum, the B12-IF complex is recognized by special receptors
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The recommended daily intake of B12 is between 2.4 and 2.8 mcg, but its low absorption rate is the reason for such high dosages in supplements (NIH, 2020)