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Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide gamma-glutamylcysteine
J Clin Invest 117:32583270
Direct impact can shear peptide bonds through mechanical force, damaging the compound before it even dissolves
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Therefore, future research efforts will be necessary to clarify the mechanism of enzyme inhibition played by auranofin on GSTs
PubMed: copper peptide angiogenesis
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