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Patients with pernicious anemia or others who cannot absorb B from food typically need lifelong B therapy, often on a monthly injection schedule

If symptoms worsen or new ones appear, re-evaluate (e.g., neurological exam, additional testing)

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Our findings extend this concept by identifying a subtype-specific metabolic adaptation in HCC: EC maintain intracellular cysteine pools via dual mechanismscystine import through the xCT transporter and de novo synthesis via the methionine metabolism pathway

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