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More specifically, Ipamorelin may mimic the function of ghrelin by activating the ghrelin receptors there, which are also known as the Growth Hormone Secretagogue receptors 1 Alpha (GHS-R1a) Fragment 176-191 peptide , as the name suggests, is a small fragment of the growth hormone hGH composed of 15 amino acids
demonstrated that although the combination therapy (metformin 1000 mg BID + liraglutide 1.2 mg/day) resulted in a greater weight loss than liraglutide alone, both groups showed an increase in SHBG and a decrease in free testosterone, with no differences between the two treatment arms, thus suggesting that the effect on the biochemical hyperandrogenism of liraglutide may be partially independent of the extent of weight loss [60]
Ellis, R
Journal of Physiology and Pharmacology, 50(4), 675682
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