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GLP-1 initiators had higher rates of metformin use (32.7% vs

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In a recent meta-analysis of 12 observational studies of patients with T2DM treated with either SGLT2 inhibitors or GLP-1RAs, the GLP-1RA group exhibited a significantly lower relative risk of lower limb amputation vs the SGLT2 inhibitor cohort (3.54 vs 4.72 events per 1000 patient-years).37 Furthermore, in the CANVAS program involving 10,142 patients with T2DM at high cardiovascular risk, canagliflozin was found to be associated with a 1.97-fold increased risk of lower-limb amputations

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For more comprehensive discussions on prevention and treatment options tailored to specific eye diseases, see the protocols on Macular Degeneration, Retinopathy, Glaucoma, or Cataracts. 3 Understanding the Eyes Proper vision depends upon the health of a number of organs, including the eyes themselves, the muscles that support and move the eyes, the optic nerve, and various portions of the brain that sense and interpret visual input (Merck 2013)

Here's what the evidence actually says, and what it might mean for people living with type 2 diabetes