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Zepbound has shown the highest average weight loss in clinical trials
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See our BPC-157 research overview and TB-500 research overview in the Research Hub, plus the BPC-157 vs TB-500 comparison article
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In adults with overweight or obesity (without diabetes) the semaglutide 2.4 mg dose produced an average weight reduction of about 15% of baseline body weight over ~68 weeks in the STEP 1 trial, a result that surprised many clinicians because it brought pharmacologic outcomes into a range previously associated with surgical interventions
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