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After roughly four weeks of daily injection, the receptors begin downregulating
doi: 10.1210/endocr/bqab079 91 ZhuXLinCLiLHuSCaiXJiL
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Early research suggested that loading creatine at a total of 25 grams per day (split into five servings) for a week followed by reducing the dosage to five grams a day thereafter was the most effective protocol
Hsueh WA, Orloski L, Wyne K
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