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The product is likewise indicated for increased physiologic demand (pregnancy, thyrotoxicosis, chronic hemorrhage), for drug-induced depletion, and for select neurologic or hematologic disorders in which B12 plays a pivotal metabolic role
Parasutterella colonization has been shown to alter tryptophan, tyrosine, and xanthine metabolism in mouse cecal samples 61
NNMT is strongly associated with metabolic regulation, adiposity, glucose balance, and energy expenditure in animal models
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