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Sufficient membrane PL-PUFAs and free intracellular iron are required for ferroptosis ( The transferrin receptor (TfR) is an essential regulator of ferroptosis
Glutathione peroxidase (GPX) The GPX family comprises eight members (GPX1GPX8), which serve as classic antioxidant enzymes to mitigate oxidative stress and maintain redox homeostasis [27]
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To further confirm this hypothesis, DEN/CCl4-induced liver cancer xenograft mice were administered piperazine erastin in the presence and absence of Lip-1