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New England Journal of Medicine .
[58] Patients not receiving diuretic therapy may begin with 10 mg once daily, while those currently taking diuretics should start with a lower dose of 2.5 to 5 mg to minimize the risk of excessive hypotension
The Mayo Clinic data specifically showed benefits with tirzepatide, while other studies demonstrated similar benefits with semaglutide
The obesity drugs lower blood sugar and slow down digestion, so people feel full longer
The redundant GLP-1 stimulation would likely increase GI side effects without proportional benefit
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