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The main cerebral target for THC is type-1 cannabinoid receptors (CB1R), which are widely expressed in the brain and regulate various functions including neurotransmitter release, neuro-astroglial communication, and cellular bioenergetic processes [29,30,31,32]
No genotoxicity, mutagenicity, or organ-specific toxicity was reported at the doses tested in the preclinical safety evaluation
532 Another candidate, ultevursen (QR-421a), is an ASO therapy for treating vision loss in patients with pigmentary retinopathy due to mutations in exon 13 of the USH2A gene
Endurance athletes may also deplete B12 stores faster due to increased metabolic demands and potential gastrointestinal stress from long training sessions
Expert Opin Drug Metab Toxicology (2014) 10(5):699719
Richiardi, L
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