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19 and Yamada et al
Quality assessment of included studies The risk of bias in the eligible included studies was assessed using the Cochrane criteria.[] The quality of all studies was assessed by two different authors (NK and BA) for following items: sequence generation, allocation sequence concealment, blinding of participants and researchers, and outcomes reporting to evaluate possible sources of bias [Figure 1]
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Additionally, we conducted further experiments to measure the fully deuterated exchange profiles of arr1 to estimate back-exchange
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