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They often have to rely on cards outside their main engines to do it
(Damage and effects that say "destroy" don't destroy it.) Creature - Vampire Soldier Color tag templates(None) An Offer You Can't Refuse Counter target noncreature spell
PSE Prismatic Secret Rare Limited Limited Synchro Overtake X SPELL Reveal 1 Synchro Monster in your Extra Deck, choose 1 of the Synchro Materials mentioned on it, and add to your hand or Special Summon that monster, from your Deck or GY, also you cannot Special Summon from the Extra Deck the turn you activate this card, except Synchro Monsters
For instance, Force of Despair is a good way to deal with Emrakul, the World Anew, which has protection from all spells, and it can deal with other combo decks, like Living End, that play multiple creatures in one decisive turn
However, in Ishizus case, it was perfect, as her Graveyard was full of cards while Kaiba only had 6 cards